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科研论文

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1.Meng L, Yang P, Zhang W, Zhang X, Rong X, Liu H,Li M*: Brain-derived neurotrophic factor promotes orthodontic tooth movement by alleviating periodontal ligament stem cell senescence.Cell Signal. 2023 May 19;108:110724. doi: 10.1016/j.cellsig.2023.110724.

2.Kou Y, Rong X, Tang R, Zhang Y, Yang P, Liu H, Ma W,Li M*: Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal.Front Pharmacol. 2023 Mar 3;14:1067085. doi: 10.3389/fphar.2023.1067085.

3.Gao R, Zhang W, Jiang Y, Zhai J, Yu J, Liu H,Li M*: Eldecalcitol effectively prevents alveolar bone loss by partially improving Th17/Treg cell balance in diabetes-associated periodontitis.Front Bioeng Biotechnol.2023 Feb 3;11:1070117. doi: 10.3389/fbioe.2023.1070117.

4.Takahashi K, Amano H, Urano T,Li M, Oki M, Aoki K, Amizuka N, Nakayama KI, Nakayama K, Udagawa N, Higashi N: p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.PLoS One.2023 Feb 15;18(2):e0276838. doi: 10.1371/journal.pone.0276838.

5.Rong X, Kou Y, Zhang Y, Yang P, Tang R, Liu H,Li M*: ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways.Drug Des Devel Ther. 2022 Nov 15;16:3929-3946. doi: 10.2147/DDDT.S377001.

6.Zhou Q, Liu S, Kou Y, Yang P, Liu H, Hasegawa T, Su R, Zhu G,Li M*: ATP Promotes Oral Squamous Cell Carcinoma Cell Invasion and Migration by Activating the PI3K/AKT Pathway via the P2Y2-Src-EGFR Axis.ACS Omega. 2022 Oct 26;7(44):39760-39771. doi: 10.1021/acsomega.2c03727.

7.Yang P, Li C, Zhou Q, Zhang X, Kou Y, Feng Q, Wang H, Su R, Hasegawa T, Liu H,Li M*: Notum Leads to Potential Pro-survival of OSCC Through Crosstalk Between Shh and Wnt/β-catenin Signaling Via p-GSK3β.Int J Biochem Cell Biol.2022 Oct 21:106316. doi: 10.1016/j.biocel.2022.106316.

8.Moritani Y, Hasegawa T, Yamamoto T, Hongo H, Yimin, Abe M, Yoshino H, Nakanishi K, Maruoka H, Ishizu H, Shimizu T, Takahata M, Iwasaki N,Li M, Tei K, Ohiro Y, Amizuka N: Histochemical assessment of accelerated bone remodeling and reduced mineralization in Il-6 deficient mice.J Oral Biosci. 2022 Oct 11:S1349-0079(22)00131-1. doi: 10.1016/j.job.2022.10.001.

9.Hongo H, Yokoyama A, Yamada-Sekiguchi T, Yamamoto T, Yoshino H, Abe M, Haraguchi-Kitakamae M, Luiz de Freitas PH, Hasegawa T,Li M: Histochemical assessment on osteocytic osteolysis in lactating mice fed with a calcium-insufficient diet.J Oral Biosci. 2022 Sep 21:S1349-0079(22)00127-X. doi: 10.1016/j.job.2022.09.003.

10.Zhang W, Gao R, Rong X, Zhu S, Cui Y, Liu H,Li M*: Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis.Front Endocrinol (Lausanne). 2022 Sep 6;13:965258. doi: 10.3389/fendo.2022.965258.

11.Maruoka H, Yamamoto T, Zhao S, Hongo H, Abe M, Ishizu H, Yoshino H, Luiz de Freitas PH,Li M, Hasegawa T: Histological functions of parathyroid hormone on bone formation and bone blood vessels.J Oral Biosci.2022 Aug 14:S1349-0079(22)00096-2. doi: 10.1016/j.job.2022.08.002.

12.Yang P, Feng Q, Meng L, Tang R, Jiang Y, Liu H, Si H,Li M*: The mechanism underlying the TC-G 1008 rescue of reactive oxygen species (ROS)-induced osteoblast apoptosis by the upregulation of peroxiredoxin 1.Int J Biochem Cell Biol. 2022 Aug 8;151:106276. doi: 10.1016/j.biocel.2022.106276.

13.Wang C, Qi X, Zhou X, Liu H,Li M*: Diagnostic value of objective VELscope fluorescence methods in distinguishing oral cancer from oral potentially malignant disorders (OPMDs).Transl Cancer Res. 2022 Jun;11(6):1603-1615. doi: 10.21037/tcr-21-2804.

14.Zhang Y, Kou Y, Yang P, Rong X, Tang R, Liu H,Li M*: ED-71 inhibited osteoclastogenesis by enhancing EphrinB2-EphB4 signaling between osteoclasts and osteoblasts in osteoporosis.Cell Signal. 2022 Aug;96:110376. doi: 10.1016/j.cellsig.2022.110376.

15.Feng W, Yang P, Liu H, Zhang F,Li M*: IL-6 promotes low concentration of RANKL-induced osteoclastic differentiation by mouse BMMs through trans-signaling pathway.J Mol Histol.2022 Jun 6;53(3):599-610. doi: 10.1007/s10735-022-10077-7.

16.Maruoka H, Hasegawa T, Yoshino H, Abe M, Haraguchi-Kitakamae M, Yamamoto T, Hongo H, Nakanishi K, Nasoori A, Nakajima Y, Omaki M, Sato Y, Luiz de Fraitas PH,Li M: Immunolocalization of endomucin-reactive blood vessels and α-smooth muscle actin-positive cells in murine nasal conchae.J Oral Biosci.2022 May 16:S1349-0079(22)00084-6. doi: 10.1016/j.job.2022.05.001.

17.Maruoka H, Zhao S, Yoshino H, Abe M, Yamamoto T, Hongo H, Haraguchi-Kitakamae M, Nasoori A, Ishizu H, Nakajima Y, Omaki M, Shimizu T, Iwasaki N, Luiz de Freitas PH,Li M, Hasegawa T: Histochemical examination of blood vessels in murine femora with intermittent PTH administration.J Oral Biosci.2022 May 15:S1349-0079(22)00086-X. doi: 10.1016/j.job.2022.05.003.

18.Lu Y, Liu S, Yang P, Kou Y, Li C, Liu H,Li M*: Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway.Stem Cell Res Ther. 2022 Mar 21;13(1):113. doi: 10.1186/s13287-022-02800-8.

19.Jiang Y, Yang P, Li C, Lu Y, Kou Y, Liu H, Guo J,Li M*: Periostin regulates LPS-induced apoptosis via Nrf2/HO-1 pathway in periodontal ligament fibroblasts.Oral Dis. 2022 Mar 17. doi: 10.1111/odi.14189.

20.Feng Q, Yang P, Wang H, Li C, Hasegawa T, Liu Z,Li M*: ID09, A Newly-Designed Tubulin Inhibitor, Regulating the Proliferation, Migration, EMT Process and Apoptosis of Oral Squamous Cell Carcinoma.Int J Biol Sci. 2022 Jan 1;18(2):473-490. doi: 10.7150/ijbs.65824.

21.Liu S, Gao W, Lu Y, Zhou Q, Su R, Hasegawa T, Du J,Li M*: As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma.Int J Biol Sci. 2022 Jan 1;18(2):491-506. doi: 10.7150/ijbs.66841.

22.Kou Y, Jiang Y, Liu S, Yang P, Lu Y, Liu H,Li M: Regulatory T cells showed characteristics of T helper-17(Th17) cells in mice periodontitis model.Oral Dis. 2021 Nov 5. doi: 10.1111/odi.14072.

23.Kou Y, Li C, Yang P, Li D, Lu X, Liu H,Li M*: The W9 peptide inhibits osteoclastogenesis and osteoclast activity by downregulating osteoclast autophagy and promoting osteoclast apoptosis.J Mol Histol. 2021 Oct 18. doi: 10.1007/s10735-021-10030-0.

24.Yamamoto T, Hasegawa T, Fraitas PHL, Hongo H, Zhao S, Yamamoto T, Nasoori A, Abe M, Maruoka H, Kubota K, Morimoto Y, Haraguchi M, Shimizu T, Takahata M, Iwasaki N,Li M, Amizuka N: Histochemical characteristics on minimodeling-based bone formation induced by anabolic drugs for osteoporotic treatment.Biomed Res. 2021;42(5):161-171. doi: 10.2220/biomedres.42.161.

25.Lu Y, Kou Y, Gao Y, Yang P, Liu S, Zhang F,Li M*: Eldecalcitol inhibits the progression of oral cancer by suppressing the expression of GPx-1.Oral Dis. 2021 Aug 24. doi: 10.1111/odi.14010.

26.Li C, Yang P, Kou Y, Zhang D,Li M*: The polypeptide OP3-4 induced osteogenic differentiation of bone marrow mesenchymal stem cells via protein kinase B/glycogen synthase kinase 3β/β-catenin pathway and promoted mandibular defect bone regeneration.Arch Oral Biol. 2021 Oct;130:105243. doi: 10.1016/j.archoralbio.2021.105243.

27.Yamamoto T, Hasegawa T, Mae T, Hongo H, Yamamoto T, Abe M, Nasoori A, Morimoto Y, Maruoka H, Kubota K, Haraguchi M,Li M: Comparative immunolocalization of tissue nonspecific alkaline phosphatase and ectonucleotide pyrophosphatase/phosphodiesterase 1 in murine bone.J Oral Biosci. 2021 Sep;63(3):259-264. doi: 10.1016/j.job.2021.08.001.

28.Hashimoto K, Hasegawa T, Yamamoto T, Hongo H, Imin Y, Abe M, Nasoori A, Nakanishi K, Maruoka H, Morimoto Y, Kubota K, Shimizu T, Haraguchi M, Takahata M, Iwasaki N,Li M, Fujisawa T, Amizuka N: Histological observation on the initial stage of vascular invasion into the secondary ossification of murine femoral epiphyseal cartilage.Biomed Res. 2021;42(4):139-151. doi: 10.2220/biomedres.42.139.

29.Yang P, Li C, Kou Y, Jiang Y, Li D, Liu S, Lu Y, Hasegawa T,Li M*: Notum suppresses the osteogenic differentiation of periodontal ligament stem cells through the Wnt/Beta catenin signaling pathway.Arch Oral Biol. 2021 Jul 21;130:105211. doi: 10.1016/j.archoralbio.2021.105211.

30.Li C, Yang P, Liu B, Bu J, Liu H, Guo J, Hasegawa T, Si H,Li M*: Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway.J Mol Histol. 2021 Oct;52(5):1081-1095. doi: 10.1007/s10735-021-10006-0.

31.Yang P, Feng W, Li C, Kou Y, Li D, Liu S, Hasegawa T,Li M*: LPS induces fibroblast-like synoviocytes RSC-364 cells to pyroptosis through NF-κB mediated dual signalling pathway.J Mol Histol. 2021 Aug;52(4):661-669. doi: 10.1007/s10735-021-09988-8.

32.Liu D, Du J, Sun J,Li M*: Parathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase.Bioengineered. 2021 Dec;12(1):1997-2006. doi: 10.1080/21655979.2021.1928930.

33.Yokoyama A, Hasegawa T, Hiraga T, Yamada T, Yimin, Hongo H, Yamamoto T, Abe M, Yoshida T, Imanishi Y, Kuroshima S, Sasaki M, de Fraitas PHL,Li M, Amizuka N, Yamazaki Y: Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells.J Bone Miner Metab. 2021 Sep;39(5):810-823. doi: 10.1007/s00774-021-01220-7.

34.Zhang X, Zhang S, Yan X, Shan Y, Liu L, Zhou J, Kuang Q,Li M, Long H, Lai W: m6A regulator-mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis.J Cell Mol Med. 2021 Apr;25(7):3634-3645. doi: 10.1111/jcmm.16469